Поиcк препарата по названию

HistaFlex и заболевание почек / печени

Результат проверки взаимодействия лекарства HistaFlex и заболевания заболевание почек / печени на безопасность при совместном использовании.

Результат проверки:

HistaFlex <> заболевание почек / печени

Актуальность: 23.07.2019 Рецензент: Шкутко П.М., к.м.н., in

При проверке взаимодействия по данным авторитетных источников Drugs.com, Rxlist.com, Webmd.com, Medscape.com обнаружены противопоказания или побочные эффекты, которые могут нанести вред или усилить негативный эффект при использовании лекарства с данным сопутствующим заболеванием.

Потребитель:

Ограниченные фармакокинетические данные доступны для старшего, антигистаминных препаратов первого поколения. Многих появляются в основном метаболизируется в печени, и оба родителя, препараты и метаболиты выводятся с мочой. Пациентам с нарушением функции почек и/или печени, могут быть подвержены большему риску развития побочных эффектов от антигистаминных препаратов из-за наркотиков и накопление метаболитов. Терапия антигистаминными препаратами следует назначать с осторожностью в таких больных. Более низкие начальной дозы могут быть целесообразными.

Источники

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Bruce RB, Turnbull LB, Newman JH, Pitts JE "Metabolism of brompheniramine." J Med Chem 11 (1968): 1031-4
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Simons FE, Watson WT, Chen XY, Minuk GY, Simons KJ "The pharmacokinetics and pharmacodynamics of hydroxyzine in patients with primary biliary cirrhosis." J Clin Pharmacol 29 (1989): 809-15
Simons FE, Simons KJ, Frith EM "The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine." J Allergy Clin Immunol 73 (1984): 69-75
Hintze KL, Wold JS, Fischer LJ "Disposition of cyproheptadine in rats, mice, and humans and identification of a stable epoxide metabolite." Drug Metab Dispos 3 (1975): 1-9
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Huang SM, Athanikar NK, Sridhar K, Huang YC, Chiou WL "Pharmacokinetics of chlorpheniramine after intravenous and oral administration in normal adults." Eur J Clin Pharmacol 22 (1982): 359-65

HistaFlex

Непатентованное наименование: acetaminophen / pyrilamine

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Синонимы: нет

Что такое HistaFlex?